Chii chinonzi PROCYANIDIN B-2 (yakatorwa kubva kumaapuro)?

Chii icho?

Procyanidin B-2, is a subclass ye flavonoids inozivikanwa nekuita ine simba antioxidant, kurapa, uye anti-kuzvimba mhedzisiro.

Aya ma polyphenol compounds, anowanzo kuwanikwa mumaapuro, bhari, uye mhodzi dzemazambiringa, akakurudzirwa kuti abudise kukura kwebvudzi rinokurudzira mhedzisiro nekusimudzira bvudzi epithelial cell kukura uye kuitisa inoshingaira anagen kukura chikamu mu vivo murine modhi uye mu 6 mwedzi & 12 mwedzi kiriniki. miedzo.

Benefits ofPROCYANIDIN B-2

Zviito zvekudzivirira kurwisa catagen kukura, cellular DNA kuparadzwa (apoptosis), uye kurasikirwa kwebvudzi:

Ichi chidzidzo chakaongorora hukama hweProcyanidin b-2 kune TGF-beta chiratidzo nzira, dzinozivikanwa kuti dzinokurudzira chikamu checatagen (inova danho rebvudzi rinopera), uye mitogen-activated protein kinase cascade (PKC), iyo yakabatana nesero. kuwanda. Chidzidzo ichi chakawedzera TGF-beta (1) uye (2) kune vhudzi epithelial cell tsika uye yakaona kuti nzira idzi-dzinovimba dzakaderedza kukura kwesero uye kukonzeresa apoptosis (apoptosis kufa kwemasero kunoitika seyakajairwa uye inodzorwa chikamu che kukura kana kukura kwechipenyu). Zvisinei, kuwedzera kweprocyanidin B-2 kune vhudzi sero tsika yakagadzirisa izvi kukura-inodzivisa migumisiro uye yakadzivirira masero ebvudzi kubva kuapoptosis.

Pamusoro pe1,000 zvinyorwa zvechisikigo zvakaongororwa ...

Iyo proanthocyanidins (kusanganisira procyanidin b-2) kubva mumbeu yemazambiringa yakatorwa sechinhu chakakosha chakasikwa chekukura kwebvudzi, mushure mekunge masayendisiti aongorora anopfuura chiuru emhando dzakasiyana dzezvinomera. Vakaona kuti maproanthocyanidins aya akawedzera masero ebvudzi mumakonzo neinosvika 230% zvine chekuita nekudzora (100%) uye aive ne "inoshamisa bvudzi-kutenderera-kushandura chiitiko kubva pachikamu chetelogen kuenda kuchikamu cheanagen ...". Saka kubva paongororo ye1,000 pazvicherwa zvezvirimwa, mhodzi dzemazambiringa dzakapfuura dzese. Zviri mukati muzvinyorwa zvembeu yemazambiringa uye chikonzero chavo chekubudirira mukukura kwebvudzi zvinopindirana kuburikidza nemhando dzakasiyana-siyana dze phenolic, simba re antioxidant, kuvandudza kutenderera kweropa, kukurudzirwa kwe collagen nezvimwe zvikomborero. (kudzidza). Mbeu dzemazambiringa dzakatorwa dzinoumba dzakasiyana oligomeric proanthocyanidins dzinenge 3.1% PB-2 chete. Tinoda zvimwe zvePB-2 zvemukati, saka zvimedu zvembeu yemazambiringa hazvisi zvekufarira kukura kwendebvu (zvisinei zvingave zvekukura kwebvudzi).

Bvudzi Epithelial Cell Kukura Migumisiro

Kupedzisa pamusoro pemaitiro ekukura kwekusimudzira mabasa eiyi procyanidin, chidzidzo ichi chakaratidza kuti procyanidin b-2 yakaratidza hukuru hwekukura-kukurudzira migumisiro yebvudzi epithelial cell growth. Kuwana uku kunoshuma kuti procyanidin b-2 ine basa rekusimudzira kukura mumurine bvudzi epithelial masero pahupamhi hwepamusoro hwe300% maererano nekutonga muzuva re5 tsika, uye yakaratidzawo kuti procyanidin oligomers inokurudzira anagen induction mu vivo murine. modhi paanenge akaenzana kusimba seminoxidil 2%. Procyanidin b-2 yakamira seyakanyanya kukura-inokurudzira polyphenol, mukuenzanisa nePB-3 uye PC-1 (ndosaka kutorwa kwembeu yemazambiringa kusingazove kwakanakisa kunobva ndebvu).

Zvinonakidza kuziva kuti chidzidzo ichi chakangoongorora mashandisirwo emusoro weiyi procyanidin oligomers ine 1%. Ichi chidzidzo chakangoenzanisa 1% yekusangana neminoxidil 2%. Zvinogona kutaurwa kuti huwandu hwepamusoro (se5%) yeprocyanidin b-2 inogona kuenzaniswa zvakanaka neyeMinoxidil 5%.

Ichi chidzidzo chinoratidza mukana wekuvimbisa weprocyanidin b2 kuti ishandiswe seyakagadzirwa bvudzi kukura inducer.

Human Clinical Miedzo

Ichi chiedzo chekiriniki chakaongorora mhedzisiro ye1% procyanidin b2 pakukura kwebvudzi revanhu mushure mekushandisa kwemwedzi mitanhatu. Muedzo wekiriniki wakapetwa kaviri unobatanidza huwandu hwezvidzidzo zve29 zvakaitwa. Varume ve19 vari muboka reprocyanidin B-2 uye varume gumi muboka rekudzora placebo vakaiswa pasi pekuongororwa. Hapana mhedzisiro yakaipa yakaonekwa mune chero boka.

Mhinduro:

Kuwedzera kwenhamba yebvudzi rose munzvimbo yakasarudzwa yemusoro (0.5 cm square = 0.25 cm2 nzvimbo) yeboka reprocyanidin B-2 mushure memwedzi we6-yeedzo yakakura zvikuru kupfuura iyo yeboka rekutonga boka (procyanidin B-2). , 6.68 +/- 5.53 (kureva +/- SD)/0.25 cm2; 4.56 (kureva +/- SD)/0.25 cm2; P

Mhedzisiro iyi inoratidza kuti varume vakashandisa PB2 vaive nekuwedzera kukuru kwebvudzi dzakakura, huwandu hwebvudzi rekupedzisira, uye hapana akashumwa mhedzisiro.

Apo vatsvakurudzi vakaenzanisa migumisiro yavo neiyo yemishonga iripo iye zvino, vakawana kuti procyanidin B-2 yakakonzera zvishoma zvishoma bvudzi kukura kupfuura minoxidil (pa2%, kwete 5%), asi kuwedzera kukuru kwebvudzi rose kupfuura finasteride (Proscar). Kusiyana nemishonga iyi yemishonga, procyanidin B-2 haina kubudisa migumisiro yakaipa. Kurapa kweProcyanidin B-2 kunoratidza zvingangoitika semushonga wakachengeteka uye unovimbisa mhanza yechirume.

Chimwe chidzidzo chekiriniki, chakatora mwedzi gumi nemiviri, chakaongorora kushanda kwe0.7% apple procyanidin oligomers (zvakare, kuderera kwakanyanya asi mhedzisiro ichiri yakakosha).

Muedzo wekiriniki wakapetwa kaviri unobatanidza huwandu hwezvidzidzo zve43 zvakaitwa. Varume ve21 muboka reprocyanidin uye varume makumi maviri nevaviri muboka rekudzora placebo vakaiswa pasi pekuongororwa. Mumwedzi mitanhatu yekutanga, takafananidza procyanidin uye mapoka e placebo kuti aongorore mishonga yeprocyanidin oligomers. Nguva yekushandiswa kweboka reprocyanidin yakazowedzerwa kusvika kumwedzi ye12, uye nguva yenguva yekukosha kwayo yakaongororwa.

Kuwedzera kwenhamba yose yebvudzi munzvimbo yakasarudzwa yemusoro weboka reprocyanidin zvidzidzo mushure memwedzi we6-yeedzo yakanga yakakura zvikuru kupfuura yeboka reboka rekutonga (procyanidin, 3.3 +/- 13.0 (kureva +/- SD)/ 0.50 cm(2), -3.6 +/- 8.1/0.50 cm(2); maviri-sample t-bvunzo). Nguva yenguva-inotsamira kuvandudzwa kwebvudzi density yakaonekwa mune zvidzidzo zveprocyanidin. Hapana mhedzisiro yakaipa yakaonekwa mune chero yezvidzidzo. Procyanidin therapy saka inoratidza inogona kuita bvudzi-kukura basa.

Iyo Pharmacology & Pharmacokinetics yeProcyanidin B-2

Pharmacology ibazi remishonga rine chekuita nekushandiswa, mhedzisiro, uye maitiro ekuita kwezvinodhaka.

Pharmacokinetics ibazi re pharmacology rine chekuita nekufamba kwezvinodhaka mukati memuviri.

Hazvina kukosha chete kutarisa uye kuongorora maitiro ekuita kwePB-2, zvakakosha kutarisa kuti chinhu ichi chinogona kutorwa sei, kupindwa, uye kuwanikwa mubiologically kana chashandiswa pamusoro.

Ichi chidzidzo chakacherechedza kupinda kwepercutaneous kwePB2 mune lotion ine 0.0663mg chete. Mhedzisiro yacho yakaratidza kuti kunyangwe kudzika kwakadzika mulotion, chinhu ichi chakaratidza kubatsira maererano ne pharmacokinetics.

A theoretical 4-5% kusungwa kwePB2 kunofanirwa kupa uye kupinda zvinobudirira, asi cosmetic chemist yandakahaya ichandisimbisa kana izvi zvichibvira.

Izvi hazvina chepfu uye zvakachengeteka kushandiswa?

Kuongorora kuchengetedzwa kwetopical procyanidin B-2 sechinhu chinokura bvudzi, ichi chidzidzo chakaongorora mutagenicity, acute subcutaneous jekiseni, kushatirwa kwekutanga, kunzwisiswa kweganda, uye kushatirwa kwemaziso ekomboni iyi. Mhedzisiro yacho yakaratidza kuti komisheni iyi haina mutagenic mhedzisiro, haina kukanganiswa kwemaitiro, chiyero chepamutemo chiri chikuru kupfuura 2000mg (injection yepasi), hapana kushatirwa kwekutanga pakati pekuyedzwa kwetsuro, uye kushatirwa kudiki kana kwakaiswa mumaziso etsuro.

Miedzo yekiriniki yakapfuura pavanhu yakaratidzawo hapana mhedzisiro yakaipa yakataurwa. Zvidzidzo zvakambotaurwa pamurine modhi zvakaratidza hapana mhedzisiro yakaipa kana.

Mhedzisiro iyi inoratidza kuti topical procyanidin b-2 haina njodzi uye inotenderwa kushandiswa.

Mukupedzisa, Procyanidin B-2 ine mukana mukuru uye inogara ichiongororwa nekuda kwehutano hwayo hwakawanda. Kuzvipira kwaAogubio mukugadzira zvinovaka muviri, zvekuwedzera uye zvigadzirwa zvemaindasitiri akasiyana anoshandisa Procyanidin B-2 inosimbisa kuzvipira kwekambani kushandisa simba rezvinhu zvakasikwa kuvandudza hutano hwevanhu. Sezvo kutsvagisa nekunzwisisa kweProcyanidin B-2 kuri kuramba kuchishanduka, zviri pachena kuti Procyanidin B-2 ine simba ine vimbiso huru yeramangwana rehutano hwepanyama.

Miranda Zhang