Chii chinonzi Nattokinase?
Nattokinase (NK) iBacillus subtilis protein kinase, serine protease inogadzirwa naBacillus subtilis natto panguva yekuvirisa kwenatto. Iine mabasa ekunyungudutsa magwamba eropa, kuderedza viscosity yeropa, kuvandudza kutenderera kweropa, kupfava uye kuwedzera vascular elasticity.
Muna 1980, yakawanikwa muNatto kuti ine 275 amino acids yakarongedzwa nenzira yakagadziriswa, ine molecular uremu hwe 27724. Iine basa rakasiyana-siyana rekuora magwamba eropa, uye kushanda kwayo kunomiririrwa neiyo intrinsic unit FU.
Zvenyama uye zvemakemikari zvinhu
Nattokinase inokurumidza kuita denature uye inodzima patembiricha inopfuura 80 ℃, asi inodzokororwa kutonhora-inonyorova haina mhedzisiro pairi.
Nattokinase inogadzikana mukati memaminitsi e10 apo pH inokosha inowedzera kubva pa7 kusvika ku12; Kana iyo pH kukosha iri pasi pe5, inokurumidza kudonhedza uye inove isingaite.
Mushure mekusanganisa nattokinase nezvinhu zve viscous, inogona kuchengetedza basa risingapfuuri 7.5% munzvimbo ine acidic ine pH kukosha kwe2-3.
Nattokinase imorekuru hombe single cheni peptidase inogona kuputsika kuita amino acid zvimedu kana madiki mamorekuru huremu peptide cheni nematumbo ekugaya muto (chymotrypsin, trypsin, diki intestine fluid, nezvimwewo).
Nutritional value ye natto
Natto chikafu chinoshanda chinogadzirwa nesoya beans yakabikwa yakaviriswa nebhakitiriya. Pamusoro pekuchengetedza kudya kwesoya bhinzi yakasvibira, inewo mazinga akakwirira ezvimwe zvinhu zvakaita seprotein, fiber, calcium, iron, potassium, uye mavhitaminzi pane soya yakabikwa.
Izvo zviri mubiotin B1, vhitamini B2, uye mamwe maminerari, kunyanya calcium, iron, uye potassium, inotopfuura iyo mazai. Kana tichienzanisa natto nemazai nenyama yemombe, protein ye100g ye natto inofanana nemazai matatu kana 80g emombe. Iyo amino acid yemukati mu natto zvakare yakapfuma kwazvo, iyo inokonzerwa nekugadzirwa kwemhando dzakasiyana dzevhitamini uye enzyme panguva yekuvirisa, senge amylase, protease, lipase, cellulase, nattokinase, lysozyme, glutamic acid transpeptidase, nezvimwewo. kuita kwema enzymes, mapuroteni uye zvimwe zvinovaka muviri zvakaora, saka mwero wekugaya we natto (85%) wakakwira kupfuura wesoya yakabikwa (68%), inovaka muviri uye iri nyore kutora.
Tsvakurudzo yebasa
NattoKinase (NK) ipuroteni ine huremu hwemamorekuru idiki zvakanyanya pane UK, SK, uye tPA, inotorwa kubva muchikafu natto kana kuviriswa nenatto bacteria. Inogona kutorwa neura. Iyo in vitro uye in vivo thrombolytic zvimiro zveNK zvakatemwa kuburikidza nekuyedza, uye zvakaonekwa kuti in vivo thrombolytic chiitiko cheNK chakapetwa kana pane yefibrinolytic enzyme. Inoita nekukurumidza uye inogara kwenguva yakareba mu vivo, uye inogonawo kuita tPA mumuviri, ichiita kuti ive nyoro Ramba uchivandudza fibrinolytic basa reropa. Varwere vari panjodzi yemyocardial infarction vanoda jekiseni 300000 mayuniti eurokinase panguva, uye 50 magiramu e natto ane 800000 mayuniti eurokinase ye thrombolysis.
Main mabasa
mhedzisiro inokosha ye nattokinase inonyanya kushanda pakurwisana neropa rekare. Nattokinase inowana yakananga thrombolytic mhedzisiro kuburikidza nehydrolyzing iyo main fibrin yethrombus, uye parizvino ndiyo yega chinhu chakasikwa chinowanikwa kunyungudutsa yekare thrombus.
Muna 2015, Tokyo Medical University yakaita ongororo yethrombolytic nattokinase muvanhu, ichisimbisa kuti nattokinase inogona kuwedzera kugona kwemuviri wefibrinolytic nekunyungudutsa magwamba eropa. Chirevo chekutsvagisa chakanzi "Single dose oral nattokinase thrombolysis uye anticoagulation enhancement" uye inoburitswa muScientific Reports 2015; 5: 11601.
Muna 2016, mukuedza kwemaawa 48 thrombolysis, 300FU ye nattokinase yakashandiswa kune thrombi yekare kupfuura maawa 56, zvichiratidza kuti thrombus yakanyungudutswa zvachose mukati maawa maviri; Iyo thrombolysis kumhanya kwekushandisa 150FU nattokinase yakanyanya kukwirira kupfuura iyo yekushandisa yakaenzana yakafanana neurokinase [1]. Tsvagiridzo yakaratidza kuti nattokinase haina mhedzisiro paplasma fibrinogen, zvichiita kuti isanyanya kubuda ropa. Iyo inogona zvakare kunyatso mutsa muviri wega thrombolytic meshini, ichiita kuti muviri udzivirirwe kune thrombosis kuburikidza nekushandiswa kwenguva refu, nekudaro kuve nechokwadi chemoyo uye cerebrovascular hutano.
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Nguva yekutumira: Sep-11-2023
