Deoxyarbutin, seanokwikwidza Tyrosinase inhibitor, inogona kugadzirisa kugadzirwa kwe melanin, kukunda pigmentation, kupera kweganda mavara matema, uye kuve nekukasira uye nekusingaperi ganda rekuchena. Iyo inhibitory mhedzisiro ye deoxyaarbutin paTyrosinase zviri pachena kuti yakakwirira kune mamwe machena activator, uye kuchena uye kupenya mhedzisiro inogona kuwanikwa nekushomeka kwekushandisa. Deoxyarbutin zvakare ine yakasimba antioxidant mhedzisiro
- Chinese zita Deoxyarbutin
- Zita rekunze Deoxyarbutin
- Nickname p - (tetrahydro-2H-pyran-2-oxy) phenol
- Mushonga wemakemikari C11H14O3
- Molecular uremu 194.23
- CAS login nhamba 53936-56-4
- Chirungu alias 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Kuchena ≥ 98%
Deoxyarbutinsechizvarwa chitsva chezvizoro zvinopenya uye kuchena inoshanda mumiriri, inonyanya kushandiswa mune advanced whitening cosmetics.
Test
Modulation ye melanogenesis mu melanocytes inogona kuwanikwa uchishandisa makemikari anogovera zvimiro homologies neiyo substrate tyrosine uye nekudaro nemakwikwi inhibitisa catalytic basa re tyrosinase. Isu takagadzira nyowani tyrosinase inhibitor, deoxyArbutin (dA), zvichibva pane ichi chimiro. DeoxyArbutin inoratidza kudzivirirwa kunoshanda kwehowa tyrosinase in vitro ine Ki iyo yakadzikira kagumi iyo hydroquinone (HQ) uye 350-yakaderera pane arbutin. Mumuenzaniso usina bvudzi, une pigmented guinea pig model, dA yakaratidza kukurumidza uye kwakasimba kupenya kweganda kwakanyatsogadziriswa mukati memavhiki masere mushure mekumira mukushandiswa kwepamusoro.
Kusiyana neizvi, HQ yakakonzera kupenya kweganda kupfupi asi kusinga gadziriswe nepo kojic acid ne arbutin zvisingaratidzi kupenya kweganda. Mhedzisiro kubva pachikwata chebvunzo dzekuchengetedza dzakatsigira kugadzwa kwese kweDA semorekuru rinoita. Muchiyedzo chekiriniki chemunhu, kurapwa kwepamusoro kweDA kwemavhiki gumi nemaviri kwakakonzera kudzikiswa kwakakosha kana kudiki mukureruka kweganda rose uye kuvandudzwa kwema solar lentigines muhuwandu hweganda rakajeka kana dema ganda vanhu, zvichiteerana. Iyi data inoratidza kuti dA ine inogona kuita tyrosinase inhibitory chiitiko chinogona kukonzera kupenya kweganda uye inogona kushandiswa kunatsiridza hyperpigmentary maronda.
Nhanganyaya
Melasma (chloasma) chirwere chakajairika cheganda chepigmentary chinoratidzwa nechiedza chisingaenzaniswi kune zvigamba zvitsvuku kumeso, izvo zvinowanzokonzera kuremerwa kwepfungwa uye kwepfungwa kune vanhu vakabatwa. Nekudaro, zviitiko zvinokurudzira zvepathogenesis ye melasma hazvinzwisisike. Melasma inonyanya kuwanda muvanhu vane Fitzpatrick ganda mhando IV kusvika VI pane avo vane ganda rakatsetseka (mhando I kusvika III). Melasma inozivikanwa zvakare kuve yakajairika pakati pevakadzi kupfuura varume uye yakajairika pakati pevaAsia, Latinos neAfrica-America kupfuura pakati peCaucasians. Inofungidzirwa kuti 50% kusvika 70% yevakadzi vane pamuviri muUnited States vanoita melasma [3].
Izvo zvakasimbiswa kuti iyo hyperactive melanocytes mu melasma ganda inoburitsa yakawanda melanin pigment kuburikidza ne tyrosine catabolism nzira. Tyrosinase (EC 1.14.18.1), mhangura-ine glycoprotein, ndiyo chiyero-inogadzirisa enzyme inokosha kune iyi nzira. Melanin synthesis inoitika mukati meakanyanya hunyanzvi organelles anonzi melanosomes uyezve melanosomes melanosomes inotamiswa kubva kumelanocytes kuenda kune yakavakidzana keratinocytes, nekudaro inosarudza inoumba uye inogoneka ruvara rweganda. Mazhinji ekuvhenekesa ganda maajenti anonangwa pakudzora melanin synthesis kuburikidza nekudzvinyirira kwe tyrosinase chiitiko. Kwemakore makumi mashanu apfuura, hydroquinone (1, 4-benzenediol, HQ) yakashandiswa zvakanyanya seyero yegoridhe yeprototypical tyrosinase inhibitors mukurapa melasma. Zvakadaro, kutarisisa kwazvino uno kwakabhadharwa kune njodzi yehutano inogona kuitika kwenguva refu kuHQ, senge exogenous ochronosis, leukoderma (occupational vitiligo), uye kunyange carcinogenesis. basa, kupa mukana wekuchena kweganda. Zvichakadaro, izvi zvinoumba monophenol zvinopawo kusimuka, kuburikidza ne enzymatic oxidation ne tyrosinase, kune akawanda emahara radicals anokonzera lipid peroxidation uye zvinokonzerwa ne melanosomal membrane kukuvara .Muzvidzidzo zvekare kubva murabhoritari yedu zvakaratidzwa kuti deoxyarbutin (4- [(tetrahydro-2H) -pyran-2-yl) oxy] phenol, D-Arb), inotorwa neglucoside yeHQ, haina kuchengeteka uye haina cytotoxic kana ichienzaniswa naamai vayo mukomboni hydroquinone. Chidzidzo chazvino chakaitwa kuti chiongorore kutyisa uye kushanda kweD-Arb padanho re-sub-cellular (zvakananga pamelanosomes) uye kupenya kweganda uchishandisa mu vivo uye in vitro modhi, ichienderera mberi nekuongorora biosafety yeD-Arb mukufananidza neHQ. kushandiswa kwekupenya kweganda.
Deoxyarbutin, sechizvarwa chitsva chezvizoro zvinopenya uye kuchena zvinoshanda mumiririri, inonyanya kushandiswa mune advanced whitening cosmetics.
D-Arbutin ndechimwe chezvinobva kuArbutin, inonzi D-nenenebb arbutin, iyo inogona kunyatso kuvharidzira kuita kwe tyrosinase munyama yeganda. Zvinoenderana netsvagiridzo, mhedzisiro yayo inotosvika gumi nguva yehydroquinone uye 350 nguva iyo yeGeneral Arbutin. Mune bvunzo dzeganda remhuka, iyi D-Arbutin inogona kukurumidza uye nekunyatso chena ganda, uye mushure mekurega kushandisa, mhedzisiro yacho inogona kuramba ichichengetwa kweanoda kusvika mavhiki masere.
Muzvidzidzo zvekiriniki pamuviri wemunhu, kushandiswa kwepamusoro kweD-Arbutin kwemavhiki gumi nemaviri kunogona kuwana mhedzisiro yekupenya kweganda, uye ine yakanaka yekuvandudza mhedzisiro pane zuva nezuva mwenje mwenje uye rima mamiriro eganda.
Nguva yekutumira: Jul-11-2023
