Munyika yemishonga uye inovaka muviri, Noopept iri kuwana kutarisisa seyakagoneka yekuziva inosimudzira uye neuroprotectant. Aogubio ikambani inotungamira inoshanda mukugadzira uye kutengeswa kwemishonga inoshanda nemishonga, mbishi uye zvirimwa zvinotorwa, kusanganisira Noopept. Mushonga wekugadzira wakagadzirwa nekambani yeRussia, Noopept inowanzonzi nootropic nekuda kwekugona kwayo kugadzirisa-kukurudzira zvinhu. Mune ino blog, isu tichaongorora mabhenefiti uye mashandisiro eNoopept, pamwe nekugona kwayo kukanganisa basa rekuziva uye hutano hwese.
Chii chinonzi Noopept?
Noopept, iyo inozivikanwawo seN-phenylacetyl-L-prolylglycine ethyl ester, ikemikari inodzidzwa nokuda kwekugona kwayo kuvandudza kushanda kwekuziva uye kurwisana nekuzvidya mwoyo. Noopept's structure yakabva paPiracetam, imwe inozivikanwa nootropic, iyo yakaratidzwa kuva neuroprotective properties uye inogona kuva nemigumisiro yakanaka pakuyeuka nekudzidza. Aogubio iri pamberi pakupa Noopept yepamusoro-soro kuti ishandiswe mukuwedzera, mishonga uye mamwe maindasitiri.
Iyo Noopept Inoshanda
Noopept inonyanyozivikanwa cognitive-enhancing drug inoshanda nekukurumidzira nzira yekugadzira chiyeuchidzo uye kutorazve. Inoita izvi nekusimudzira mazinga ehuropi-derived neurotrophic factor (BDNF), komisheni inokurudzira kukura kwemasero europi. Uyewo, Noopept inoita kuti acetylcholine (ACh) inogamuchirwa muuropi iwedzere kupindira kune neurotransmitter (brain chemical) acetylcholine, iyo inobvumira kukurumidza uye kwakanyatsogadzirisa kutumira kwemashoko pakati peeuroni.
Benefits of Noopept
Inovandudza Basa reKuziva
Huwandu hwakawanda hwehumbowo hwekiriniki hunotsigira mabhenefiti eNoopept munzvimbo dzakasiyana-siyana dzekuziva senge ndangariro, kudzidza, uye kugona kufunga:
- Mune varwere vane kuvhiringidzika kwepfungwa kunokonzerwa nekushungurudzika kana zvirwere zvepfungwa dzevascular, Noopept yakavandudza uropi hunoita sezvinoratidzwa nekuwedzera alpha- uye beta-rhythms simba mu electroencephalogram (EEG).
- Kutungamirirwa kweNoopept pachiyero che 20 mg zuva rega rega kwemwedzi ye2 yakavandudza ruzivo rwekuziva kune varwere vane sitiroko uye ine yakakwirira yekuchengeteka.
- Mumhando dzinoverengeka dzemhuka dzechirwere cheAlzheimer (AD), Noopept yakadzivirira masero europi hwegonzo kubva kune amyloid beta toxicity (causative agent yeAD) nekudzivisa kukuvadzwa kweoxidative, kudzivirira calcium kuwandisa, uye kudzvinyirira apoptosis (yakarongwa sero kufa).
- Kudzokororwa kwemuromo kutungamirirwa kweNoopept mumakonzo kwakavandudza kudzidza kana kuenzaniswa nedoro rimwe chete.
- Mune rat modhi yesitiroko, Noopept yakaratidza zvese cognition-kudzoreredza uye neuroprotective zvivakwa.
- Mune zvakajairika uye Down's syndrome uropi hwemunhu neurons, Noopept yakadzivirira oxidative kukuvara uye apoptosis.
- Mumakonzo anoziva, Noopept manejimendi akawedzera basa rehuropi muEEG.
- Noopept ine simba rekuwedzera mazinga eNerve Growth Factor uye Brain Derived Neurotrophic Factor, iyo inobatanidza nekusingaperi kuvandudzwa mukuyeuka.
- Noopept inogona kubatsira kuvandudza basa rekuziva nekusimudzira masaini emagetsi pakati peeuroni.
- Noopept pa 1: 1 chiyero kana gumi-yakawanda yakakura yakaonekwa kuderedza zvakanyanya mazinga eLewy miviri (protein clumps inokonzera Parkinson's disease) muuropi.
- Mune makonzo ane convulsive disorder, kusingaperi kutonga kweNoopept kwakawedzera kushanda kweiyo anticonvulsant drug valproate.
- Chidzidzo chakashuma kuti Noopept inoshandisa neuroprotective yayo mhedzisiro kuburikidza neiyo antioxidant uye anti-inflammatory properties.
- Mumakonzo, Noopept yakasimudzira kutapurirana kwezviratidzo zvetsinga muuropi.
- Mumakonzo, Noopept yakadzivirira zvachose kukura kwekusagadzikana kwepfungwa kunokonzerwa ne scopolamine.
- Mumakonzo, Noopept yakashandura kukanganisa kwekuziva nekuwedzera mazinga ehuropi-derived neurotrophic factor (BDNF).
- Mumuenzaniso wembeva wechirwere cheAlzheimer, Noopept yakadzivirira kuderera kwendangariro.
- Zvidzidzo zvakashuma kuti Noopept inogona kubatsira kudzivirira chirwere cheAlzheimer nekudzivisa kuumbwa kwemaitiro eprotein asina kujairika muuropi uye kuderera mubasa rekushungurudzika-activated mitogen-activated protein kinases (MAPK).
- Mune makonzo, jekiseni reNoopept 5 maminetsi asati adzidza akavandudza ndangariro dzenguva refu.
- Mumakonzo ane sitiroko, kurapwa kweNoopept kwakaderedza infarction nzvimbo (tishu yakafa) muuropi.
- Mumakonzo, Noopept administration pa 5 mg/kg kuburikidza nejekiseni yakabudiswa cognitive-enhancing effects.
- Kutungamirirwa kwe0.5-10 mg / kg yeNoopept mumakonzo yakakurudzira imwe-sesion yekudzidza mushure mekutonga kumwe chete, nepo kudzokororwa kwekutonga kwakawedzera kukwanisa kudzidza kwemakonzo akakundikana kudzidziswa kwekutanga mubasa rekudzivisa (muedzo unoongorora kudzidza nekuyeuka) .
- Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) kutungamirirwa pamwero we 0.5 mg / kg 15 maminitsi kusati kwatanga maze yeMorris yakakonzera kuvandudzwa kukuru mukuyeuka kwenguva refu.
- Mumakonzo ane compression-induced cerebral ischemia, Noopept administration kuburikidza nejekiseni uye nzira yemuromo yakagadziridzwa kudzoserwa kwemaitiro ekudzivisa mhinduro.
- Chidzidzo chesero chakawana kuti Noopept yakadzivirira neurodegeneration inokonzerwa ne glutamate uye oxidative kusagadzikana.
- Mumakonzo aive nekukanganisa kwekuziva nekuda kwelobectomy, chirongwa chinosanganisira kubviswa kwerobe rose rehuropi, Noopept akakurudzira kudzoreredzwa kwekudzidza nekuyeuka.
- Chidzidzo chesero chakashuma kuti Noopept yakasimudzira kutapurirana kwezviratidzo pakati pemasero ehuropi.
Anorwisa Kuzvidya Mwoyo
- Noopept's cognitive-enhancing hunyanzvi zvakare inoburitsa anti-kufunganya maitiro zvinoenderana nezvidzidzo:
- Kutungamirirwa kweNoopept kune varwere vane unyoro hwekunzwisisa kukanganisa kwakaderedza kuneta, kuzvidya mwoyo, uye kutsamwa.
- Mune varwere vane ichangobva kuongororwa yekufema tuberculosis, Noopept kurapwa kwakaderedza kuratidzwa kwekuzvidya mwoyo.
- Mumakonzo, Noopept manejimendi yaisanganiswa nekuwedzera kweiyo locomotor chiitiko mune yakakwira plus-maze bvunzo, zvichiratidza kurwisa-kuzvidya moyo.
- Noopept manejimendi yakawedzerawo maitiro ekuongorora makonzo arikuvhurika bvunzo, izvo zvinoratidza kuderera kwekushushikana.
- Mune mbeva, kutonga kweNoopept kwakagadzira modulation yezinga rekushushikana.
- Mumakonzo, Noopept yakaderedza chiitiko chekudzidzira kusabatsira.
- Mumakonzo kubva kumarudzi akasiyana-siyana, Noopept yakaderedza kushushikana kwemazinga sezvinopupurirwa nekuwedzera kwenhamba yekudzivisa maitiro mukushungurudzika-inducing slip-funnel test.
- Mumakonzo ane makore 4 mazuva, Noopept akadzora zviratidzo zvekushungurudzika kunokonzerwa necorticotropin inobudisa hormone (CRH).
- Mune inbred mice strains, Noopept administration pa 1 mg per kg zuva nezuva yakabudisa anti-anxiety effects pazuva re7th.
Inovandudza Mood
Noopept inogonawo kubatsira kuvandudza mafungiro, zvichiita kuti ive sarudzo yekurapa kune mamwe matambudziko ehutano hwepfungwa:
- Nguva yakareba yeNoopept administration (mazuva 21) yakabvisa zvakanyanya kuratidzwa kwekudzidzira kusabatsira kana kuenzaniswa neAfobazol anti-anxiety drug.
- Kutonga kwenguva refu (28 mazuva, 0.5 mg / zuva kuburikidza nejekiseni) yeNoopept yakavandudzwa maitiro nekuderedza basa rekushungurudzika-induced kinases (inobatanidzwa mumatambudziko epfungwa) uye kuwedzera mazinga eBDNF.
Muchidimbu, Noopept ikamu rinovimbisa rine zvingangobatsira pakuziva basa, kufunganya, uye mafungiro. Aogubio inzvimbo yakavimbika yeNoopept yemhando yepamusoro uye zvimwe zvinhu zvine chekuita nemishonga, kuve nechokwadi chekuti vatengi vawana mhinduro dzakavimbika, dzinoshanda dzehutano hwavo uye hutano zvinodiwa. Ingave yakashandiswa mukuwedzera, mishonga, kana mamwe maapplication, Noopept ine mukana wekuita mutsauko unokosha muhupenyu hwevashandisi. Sezvo kudiwa kweakasikwa cognitive enhancers kuri kuramba kuchikura, AoguBio inoramba yakazvipira kupa zvigadzirwa zvitsva kuti zvizadzise zvinogara zvichichinja zvinodiwa nevatengi vedu.
Kunyorwa kwechinyorwa:Miranda Zhang
Nguva yekutumira: Mar-11-2024
