Chii chinonzi Spermidine & nicotinamide mononucleotide (NMN)?
Spermidine is polyamine, zvinoreva kuti ine maviri kana anopfuura ekutanga amino mapoka. Izvo zvinongoitika uye zvinosangana zvakanyanya mu ribosomes uye mhenyu tishu. Inobata basa rinokosha mukushanda kwesero uye kurarama.
Spermidine yakatanga kuwanikwa muna 1678 nemusayendisiti wechiDutch Anton Van Leeuwenhoek mumuenzaniso wembeu yemunhu. Nguva pfupi yapfuura, spermidine yakawanikwa mumbeu yemunhu. Mumuviri, spermidine inogadzirwa kubva kune yayo precursor putrescine. Ndiyo inotangira imwe polyamine inonzi spermine, iyo yakakoshawo kune cellular function.
Spermidine uye putrescine inozivikanwa kuti inokurudzira autophagy. Sisitimu inopwanya tsvina mukati memasero uye inodzokorodza zvikamu zvemasero. Iyo yakakosha yemhando yekudzora maitiro eiyo mitochondria, iwo masimba emasero edu. Autophagy inobvumira mitochondria yakakuvadzwa kana isina kukwana kuti iputswe uye kuraswa. Kuraswa kwemitochondria kunodzorwa zvakanyanya kupfuura zvaimbotendwa.
Polyamines inogona kusunga kune akawanda akasiyana marudzi emamorekuru achiita kuti abatsire zvakanyanya. Vanotsigira maitiro, anosanganisira kukura kwesero, kugadzikana kweDNA, kuwanda kwesero, uye apoptosis [2]. Zvinotaridzawo kuti polyamines inoshanda nenzira yakafanana nekukura zvinhu panguva yekukamurwa kwesero. Ichi ndicho chikonzero putrescine uye spermidine zvakakosha pakukura kwenyama uye kushanda.
NMN imhando yemorekuru inonzi nucleotide. Nucleotides inoita mabasa akawanda mumuviri wako, kusanganisira sezvivharo zvekuvaka zveDNA.
Mukati memasero ako, NMN inoshandurwa kuita imwe morekuru inozivikanwa se nicotinamide adenine dinucleotide (NAD). Muviri wako unoda NAD kune akasiyana mabasa anobatanidzwa mumetabolism uye kugadzirwa kwesimba.
Iwe unogona kufunga nezveNMN seyakabikwa uye NAD seyakanatswa vhezheni iyo muviri wako unogona kunyatso kushandisa.
Huwandu hweNAD hunogona kuitwa nemuviri wako zvinoenderana nehuwandu hweNMN huripo mumuviri wako.
Ndezvipi zvekudya zviri muspermidine &nicotinamide mononucleotide (NMN)?
Kune zvakawanda zvekudya zvekudya zvespermidine zvinosanganisira mazambiringa, soy zvigadzirwa, nyemba, chibage, zviyo zvakakwana, chickpeas, peas, green pepper, broccoli, maranjisi, green tea, rice bran, uye fresh green pepper.
Inogonawo kuwanikwa mushitake howa, zviyo zveamaranth, gorosi germ, cauliflower, broccoli, uye dzakasiyana siyana dzakakura chizi, uye durian.
Zvakakosha kucherechedza kuti zvakawanda zvezvokudya zveMediterranean zvine spermidine yakafuma zvokudya. Izvi zvinogona kutsanangura zviitiko zve "blue zones" uye nei vanhu ikoko vachigara kwenguva refu kupfuura kumwewo.
NMN pachayo chinhu chiri mumuviri wemunhu, chiripo mumukaka wezamu uye chikafu, senge edampoa, broccoli, cucumber, kabichi, avocados, matomatisi, nezvimwewo, asi zvirimo zvidiki kwazvo (0.25-1.88 mg pa100) magiramu). Nyama yemombe mbishi uye shrimp zvakare ine zvishoma zvishoma (0.06-0.42 mg pa100 g) yeNMN.
Zvakanakira zve spermidine &nicotinamide mononucleotide (NMN):
Spermidine inosunga kuNMN, ichinyatso kusimudzira mabhenefiti avo
Spermidine uye autophagy:Spermidine inoitawo basa repakati mune akati wandei akakosha biological process，Kugona kwespermidine kukonzeresa autophagy inofungidzirwa kuti ndiyo nzira huru iyo inoita seinononoka kuchembera uye kutsigira hupenyu hurefu.
Spermidine anti-inflammatory properties:Zvinogamuchirwa nevakawanda kuti nepo kuzvimba kuchibatsira pakupora maronda uye kudzinga utachiona hunopinda nechisimba, kuzvimba kunoramba kuripo kunoenderana nekukwegura, kunowanzonzi kuzvimba, kunokuvadza. Kuzvimba kusingaperi kunodzivirira kudzoreredzwa kwetishu, kukonzeresa masero edziviriro kuti asashande, uye anogona kutomhanyisa kumhanya uko masero ane hutano anova senescent. Spermidine inoita seinoderedza kuzvimba kusingaperi uye inogona kudzikamisa imwe nzira iyo masero nematumbu anokura.
Spermidine uye inogona kunonoka kukwegura:Pamberi pehupenyu hurefu, kutungamirirwa kwe spermidine kwakaratidzwa kuwedzera hupenyu muhuwandu hwezvidzidzo zvemhuka uye kunodzivirira chiropa fibrosis uye hepatocellular carcinoma. Izvi zvinoratidzikawo kunge zvakadaro nekudya kwakapfuma mu polyamines. Panewo humwe uchapupu hunoratidza kuti hunovandudza kurwisana nekushungurudzika uye kuti kuderera kwezera re spermidine kunotsigira kutanga kwezvirwere zvine chokuita nezera.
Spermidine inogona kuderedza kuderera kwekuziva:Tsvagiridzo yakaburitswa muna 2021 mujenari Cell Reports inopa yakadzama nhoroondo yezvekudya spermidine kuvandudza cognition uye mitochondrial basa munhunzi nemakonzo, paine mamwe angangove data revanhu kuti awedzere. Kunyange chidzidzo ichi chainakidza, chaive nezvimwe zvisingakwanisi, uye imwezve data-yemhinduro yedosi inodiwa pasati paitwa mhedziso yakasimba pamusoro pezvakanakira kuziva kwevanhu.
Inovandudza Brain Function:NMN yakaratidzwa kuvandudza cognition mumakonzo ane Alzheimer's uye kuderedza brain plaques uye neurodegenration muAlzheimer's mice. Kunyange zvazvo Alzheimer's iri chirwere chekupedzisira, vanhu vakuru vakawanda vanotamburawo nekusaziva - kusakwanisa kudzidza, kuyeuka, uye kufunga zvakanaka. Uku kukanganisa kwekuziva kwezera kwakadziviswa neNMN mumakonzo. Kukanganisa kwekuziva dzimwe nguva kunobatanidzwa nekuora mwoyo, iyo yakaratidzawo kuderedzwa neNMN mumakonzo.
Nekuda kwekuti tsinga dzedu dzeropa dzinotadza kushanda zvakanaka patinenge tichikura, kuyerera kweropa kuhuropi hwedu kunova kunokanganisa, zvichikonzera kukanganisa kwenjere. NMN yakaratidzwa kuwedzera kuyerera kweropa kuhuropi uye kunatsiridza hunyanzvi hwekuziva mumakonzo. Apo tsinga dzeropa dziri muuropi hwedu dzinovharika, tinogona kuva nesitiroko, apo uropi hwedu hunokuvadzwa. NMN yakaratidzwa kwete kungononoka kutanga kwesitiroko, asiwo kudzivirira kukuvadzwa kwesitiroko, nekuvandudza cognition uye hutano hwemitochondrial mushure mekurova mumakonzo.
Inovandudza Tsandanyama Basa:Tinovimba netsandanyama dzedu dzeskeletal pakufamba, kugadzikana, uye simba. Patinenge tichikura, mhasuru dzedu dzinorasikirwa nekukwanisa kuvandudza nekukura, zvichiita kuti kuderera kunoenderana nezera musimba remhasuru uye saizi inonzi sarcopenia. Pamwe chete nekushaya simba kwetsandanyama, tinowedzerawo kuneta uye tine kutsungirira kwemuviri kushoma. NMN inoratidzika kudzosera mamiriro aya, sezvo imwe yevatakuri vayo yakaratidza kuwedzera simba uye kutsungirira kwemuviri mumakonzo.
Inosimudzira Hutano Mwoyo: NMN yakaratidzwa kuchengetedza kubva mukutadza kwemoyo mumakonzo. Mwoyo wedu wenyama unokosha, sezvo usingazivikanwi kuti unovandudzika. Pane kudaro, matishu akakuvadzwa anoratidza mavanga (fibrosis), zvichitungamira mukusashanda zvakanaka kwemoyo. NMN inodzoreredza mbeva yemoyo basa nekudzikisa mavanga. Kurova nguva dzose uye nguva dzose, mwoyo unoda huwandu hukuru hwesimba. Nokuda kweizvi, inoda mitochondria ine utano. NMN inovandudza metabolism yemwoyo uye inodzivirira kubva pakukundikana kwemoyo, muchikamu nekugadzirisa mitochondria.
Inodzivirira Kufutisa uye Chirwere cheshuga:Kufutisa kwakabatana nekusakwana kwakasiyana-siyana kwemetabolism, kusanganisira insulin kuramba - apo masero haakwanise kushandisa glucose nekuda kwekutadza kusaina insulin - izvo zvinogona kutungamirira kuchirwere cheshuga. Mitochondria ndiyo yekupedzisira masero ekuenda kune chikafu chatinodya kuti chishandurwe kuita simba, zvichiita kuti zvive zvakakosha mumetabolism uye zvirwere zvinoenderana. NMN yakaratidzwa kuwedzera kaviri huwandu hwemitochondria muzviropa zvembeva dzakakora, izvo zvinogona kudzivirira kubva mukufutisa. Kukurudzira kuparara kwemafuta neNMN kunogonawo kubatsira vanhu vakafutisa kurasikirwa nemafuta.
Rubatsiro rweNMN mukuchembera: NMN neNAD mazinga anongodzikira nezera, saka vaongorori vakawanda vakaratidza kuti kutora NMN supplements kunogona kubatsira nehutano hune chekuita nezera.
Chidzidzo muvarume gumi vechiJapan chakawana kuti kutora NMN (100, 250, kana 500 mg) kwakawedzera mazinga eNMN byproducts muropa, kusanganisira NAD.Insulin resistance inogona kukura neageTrusted Source uye ndicho chimwe chezvikonzero zvinoita kuti chirwere cheshuga chiwande kune vanhu vakuru. vakuru. Kutora NMN supplements kwakaratidzawo kuderedza kukotsira uye kuvandudza mhasuru kuterera muvakuru vakuru, izvo zvinogona kuvandudza hutano hwemuviri nepfungwa nezera.
Dosage
Tichifunga nezve data shoma rinowanikwa pakutora NMN supplements, zvakaoma kuona iyo yakakodzera dosi. Zvidzidzo zvakawana mabhenefiti ehutano ane madosi akaderera se250 mg yeNMN pazuva, uye Spermidine dosage ye10 - 20 mg.
Kana iwe uchida, ndapota inzwa wakasununguka kubata XI'AN AOGU BIOTECH!
Nguva yekutumira: Zvita-29-2022
