Maseru mhenyu ese anenicotinamide adenine dinucleotidekana NAD+. Iyo ine nucleotides nicotinamide mononucleotide (NMN) uye adenosine diphosphate (ADP), iyo inobatanidzwa neiyo pyrophosphate linkage. NAD + inogona kushandura zviri nyore pakati payo yakaderedzwa (NADH) uye oxidized (NAD +) nyika mukupindura kune redox maitiro ayo inotora chikamu mairi.
NAD+inoshanda semutambi akakosha mumaitiro akasiyana siyana emasero, anosanganisira simba metabolism, kugadzirisa kweDNA, uye kusaina sero. Kubatanidzwa kwaro mumaitiro aya kunonyanya kuburikidza nebasa rayo semutakuri we electron, kuvhara maerekitironi pakati pemamorekuru panguva yekuita redox.
NAD + Metabolic Nzira
NAD+metabolism inosanganisira network yakaoma yebiosynthetic uye salvage nzira. Iyo de novo biosynthesis yeNAD + inotanga neamino acid tryptophan kana nicotinic asidhi seanotangira, zvichizoguma nekuumbwa kweNMN, inozoshandurwa kuita NAD +. Neimwe nzira, maseru anogona kuponesa NAD + nekushandisa precursor mamorekuru, akadai senicotinamide kana nicotinic acid riboside, ayo anoshandurwa kuita NMN ozoita NAD +.
Iyo salvage nzira inonyanya kukosha mukuchengetedza NAD + mazinga, kunyanya panguva yemamiriro ekuda kwesimba rakanyanya kana kushomeka kwekutanga kuwanikwa. Inobvumira maseru kuti adzokorore uye ashandisezve NAD + mamorekuru, kudzivirira kupera kwawo uye kuve nechokwadi chekuenderera mberi kwekupa kwakakosha metabolic maitiro.
Zvinogona Kubatsira
NAD+yakakosha pakuchengetedza mitochondrial uye gene regulation maererano nekukwegura. Nekudaro, iyo nhanho yeNAD + mumuviri wedu inodzikira zvakanyanya nezera. "Patinokura, tinorasikirwa neNAD +. Paunenge wava nemakore 50, unenge wava neinenge hafu yemwero wawaimbova nawo pawaiva nemakore 20,” anodaro David Sinclair weHarvard University mubvunzurudzo.
Zvidzidzo zvakaratidza kudzikira kwemamorekuru anobatana nezvirwere zvine chekuita nezera zvinosanganisira kukurumidza kuchembera, kusagadzikana kwemetabolism, chirwere chemoyo, uye neurodegeneration. Akaderera mazinga eNAD + ane hukama nechirwere chezera nekuda kwekusashanda kwemasabolism. Asi kuzadzazve NAD + mazinga kwaratidza
anti-kuchembera mhedzisiro mumhando dzemhuka, kuratidza mhedzisiro inovimbisa mukudzosera kumashure zvirwere zvine chekuita nezera, kuwedzera hupenyu uye hutano.
- Kuchembera
Anozivikanwa se "varindi ve genomes," sirtuin majini anodzivirira zvipenyu, kubva kune zvinomera kusvika kune zvinoyamwisa, kubva pakuipa uye zvirwere. Kana majini akanzwa kuti muviri uri pasi pekunetsekana, sekurovedza muviri kana nzara, inotumira mauto kunodzivirira muviri. Sirtuins inotsigira kutendeseka kwegenome, inosimudzira kugadzirisa kweDNA uye yakaratidza anti-kuchembera zvine hukama mumhando yemhuka sekuwedzera hupenyu.
NAD + ndiyo mafuta anotyaira majini kuti ashande. Asi senge mota haigone kutyaira isina mafuta ayo, sirtuins inoda NAD +. Mhedzisiro kubva kuzvidzidzo inoratidza kuti kusimudza NAD + nhanho mumuviri inomutsa sirtuins uye inowedzera hupenyu mumbiriso, makonye, uye mbeva. Kunyangwe NAD + kuzadzazve kuchiratidza mhedzisiro inovimbisa mumhando dzemhuka, masayendisiti achiri kudzidza kuti mhedzisiro iyi inogona kuturikira sei kuvanhu.
- Basa retsandanyama
Sesimba remuviri, basa remitochondrial rakakosha pakuita kwedu maekisesaizi. NAD+ imwe yemakiyi ekuchengetedza mitochondria ine hutano uye yakatsiga kubuda kwesimba.
Kuwedzera NAD + mazinga mumhasuru anogona kuvandudza mitochondria yayo uye kusimba mumakonzo. Zvimwe zvidzidzo zvakare zvinoratidza kuti mbeva dzinotora NAD + boosters dzakatetepa uye dzinogona kumhanya kuenda kure pane treadmill, dzichiratidza kugona kwepamusoro kwekurovedza muviri. Mhuka dzakura dzine mwero wepamusoro weNAD + dzinopfuura vezera rayo.
- Metabolic disorders
Chichinzi denda neWorld Health Organisation (WHO), kufutisa ndechimwe chezvirwere zvatekeshera munzanga yemazuva ano. Kufutisa kunogona kutungamira kune mamwe matambudziko emetabolism akadai seshuga, iyo yakauraya vanhu 1.6 miriyoni pasi rose muna 2016.
Kuchembera uye kudya kwakawanda-mafuta kunoderedza mwero weNAD + mumuviri. Zvidzidzo zvakaratidza kuti kutora NAD + boosters kunogona kuderedza kudya-kwakabatana uye zera-kwakabatana huremu mumakonzo uye kunatsiridza kugona kwavo kurovedza muviri, kunyangwe mumakonzo akura. Zvimwe zvidzidzo zvakatodzora mhedzisiro yechirwere cheshuga mumakonzo echikadzi, zvichiratidza nzira nyowani dzekurwisa metabolic kusagadzikana.
- Mwoyo kushanda
Kunaka kwetsinga kunoita sechivhariso pakati pemasaisai ekumanikidza anotumirwa nekurova kwemoyo. Asi tsinga dzakaoma sezvatinokura, zvichikonzera kukwira kweropa, iyo inonyanya kukosha yengozi yechirwere chemoyo. Munhu mumwe chete anofa nechirwere chemwoyo mumasekonzi 37 oga oga muUnited States moga, CDC inoshuma.
High blood pressure inogona kukonzera moyo wakakurisa uye kuvharika kwetsinga dzinotungamirira kusitiroko. Kusimudzira NAD + mazinga kunopa dziviriro kumoyo, kunatsiridza mabasa emoyo. Mumakonzo, NAD + boosters yakazadza mazinga eNAD + mumoyo kusvika kumatanho ekutanga uye kudzivirira kukuvara kumoyo kunokonzerwa nekushaikwa kwekuyerera kweropa. Zvimwe zvidzidzo zvakaratidza kuti NAD + boosters inogona kuchengetedza mbeva kubva kune abnormal moyo kukura.
- Neurodegeneration
Panosvika 2050, huwandu hwepasi rose vane makore makumi matanhatu zvichikwira hunofungidzirwa kuti huchasvika mabhiriyoni maviri, inopeta nekaviri nhamba ye2015, maererano neWHO. Vanhu munyika yose vari kurarama kwenguva refu. Nekudaro, kuchembera ndiyo inonyanya kuisa njodzi kune dzakawanda neurodegenerative zvirwere zvinosanganisira Parkinson's chirwere uye Alzheimer's, zvichikonzera kutadza kuziva.
Mumakonzo ane Alzheimer's, kusimudza iyo NAD + nhanho kunogona kuderedza mapuroteni anovaka izvo zvinokanganisa kutaurirana kwesero uye kuwedzera kugona kwekuziva. Kuwedzera NAD + mazinga anodzivirirawo masero ehuropi kubva pakufa kana paine kusakwana kweropa kuyerera kuuropi. Zvidzidzo zvakawanda mumhando dzemhuka zvinopa tarisiro mitsva yekubatsira uropi kukwegura hutano uye kudzivirira kubva kune neurodegeneration.
Pls ndapota taura naAlisa weCOA uye mutengo wezvinhu kuburikidza nekutengesa02@imaherb.com
Nguva yekutumira: Zvita-26-2023
